These include antihistamines as well as products that contain magnesium or aluminum. Some medications can also harm the kidneys. Dosing. Standardized rhapontic rhubarb extract (also called "false rhubarb" or "Siberian rhubarb") is easily found in a handful of supplements - usually marketed as "menopause relief" blends - here at home. Song, H., Wang, Z., and Zhang, F. [Investigation of urinary interleukin-6 level in chronic renal failure patients and the influence of Rheum palmatum in treating it]. Jiao, D. H. [Alcoholic extract tablet of rhubarb in treating acute upper gastrointestinal hemorrhage]. A meta-analysis suggests that rhubarb adjuvant to early enteral nutrition may benefit patients with severe acute pancreatitis(35), but a systematic review does not support its use for gastrointestinal failure in ICU patients(36). Wang, Z., Wang, G., Xu, H., and Wang, P. [Anti-herpes virus action of ethanol-extract from the root and rhizome of Rheum officinale Baill.]. Estrovive is a supplement for people experiencing menopause. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Z., and Xiao, X. H. Nephrotoxicity study of total rhubarb anthraquinones on Sprague Dawley rats using DNA microarrays. Interactions 9/8/201931 Interaction with cardiac glycosides (digoxin) and a reduction in the absorption of orally administered drugs have been noted when rhubarb is taken in large quantities. Ji, S. M., Li, L. S., and Ji, D. X. Efficacy of the special extract ERr 731 from rhapontic rhubarb for menopausal complaints: a . PMID: 20170496; PMCID: PMC2837008. Melanosis Coli due to Rhubarb Supplementation. If you take warfarin, do not take excessive amounts of rhubarb. Some medications for inflammation include dexamethasone (Decadron), hydrocortisone (Cortef), methylprednisolone (Medrol), prednisone (Deltasone), and others. Animal studies suggest the potential for liver toxicity at high doses and with long-term use. I did not want to do HRT so started taking this. However, the capsules contain gelatin, so they are not suitable for people following vegan or vegetarian diets. Hepatobiliary.Pancreat.Dis.Int 2004;3(3):375-380. Jiao D, Shen X, Gao Y, and et al. 1993;13(5):286-8, 261-2. View abstract. Estrovera claims itself as a new gold standard for menopause relief That relieves menopausal symptoms like hot flashes, sleep disturbances, irritability, etc. Call us at 833-347-1665 to make an appointment. Taking rhubarb along with "water pills" might decrease potassium in the body too much. Our articles are resourced from reputable online pages, with research drawn from academic institutions and peer-reviewed studies. The dosage of ERr 731 (rhapontic rhubarb) is 1 tablet/day. Disclaimer: The information provided on this site is intended for your general knowledge only and is not a substitute for professional medical advice or treatment for specific medical conditions. Wei, J., Ni, L., and Yao, J. Menopause supplements: Effectiveness, side effects, and safety. Zhonghua Yi.Xue.Za Zhi. Zhang, Z. J., Cheng, W. W., and Yang, Y. M. [Low-dose of processed rhubarb in preventing pregnancy induced hypertension]. Low molecular weight tannins, purified from rhubarb, produced an increase in glomerular filtration rate, decreased levels of uremic toxins, and increased blood flow to the kidneys.25, 29, 30, 31, 32, Use of rhubarb extract in patients with elevated serum creatinine has been reported to prevent progression of CRF. View abstract. 1 On this basis, extracts of rhubarb have been tried for control of menopausal symptoms.In a 12-week, double-blind, placebo-controlled trial of 109 women with menopause-related problems, use of a standardized Rheum rhaponticum. Researchers Marianne Heger, MD, of Health Research Services Ltd. in St. Leon-Rot, Germany, and colleagues say the rhubarb extract appeared to be safe and was well-tolerated. 1996;16(11):649-651. TCM doctors use rhubarb root to treat constipation, high fever, abdominal distension, gall stones, jaundice and, surprisingly, acute dysentery, due to the herb's anti-bacterial activity. Rhubarb Extract May Treat Symptoms of Perimenopause in Women. J Ethnopharmacol. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. View abstract. Matsuda, H., Morikawa, T., Toguchida, I., Park, J. Y., Harima, S., and Yoshikawa, M. Antioxidant constituents from rhubarb: structural requirements of stilbenes for the activity and structures of two new anthraquinone glucosides. For treatment of cold sores: a cream containing 23 mg/gram each of rhubarb extract and sage extract applied every 2 to 4 hours while awake, with treatment starting within one day of symptom appearance and continuing for 10 to 14 days. SSO.Schweiz.Monatsschr.Zahnheilkd. Learn about the effectiveness, side effects, and. Zhong.Xi.Yi.Jie.He.Za Zhi. Crit Rev Food Sci Nutr 1998;38(6):421-464. Other animal studies suggest potential for liver toxicity at high doses and with long-term use, in part due to anthraquinone compounds such as rhein and emodin as well as tannins(40). Influences of processed rhubarbs on the activities of four CYP isozymes and the metabolism of saxagliptin in rats based on probe cocktail and pharmacokinetics approaches. Clinical study on rhubarb extract tablet in treating simple obesity. View abstract. Our highly-specialized educational programs shape leaders to be at the forefront of cancer care and research. Patients and physicians should be aware of the potential for additive effects. 2002;22(4):264-266. Applied in the field of medicine, often used as drug supplements or OTCS ingredients, with good efficacy in treating cancer and cardiovascular diseases. Mao QL. Chinese Journal of Integrated Traditional and Western Medicine 2001;7(3):186-189. People experience menopause symptoms that range from mild to severe. Ma, L. [Experimental study on the immunomodulatory effects of rhubarb]. View abstract. Preliminary data suggest rhubarb may have added benefits for patients with sepsis when used with the protease inhibitor ulinastatin(34), or may help treat recurrent aphthous stomatitis(25). View abstract. Zhong.Xi.Yi.Jie.He.Xue.Bao. It has been consumed for centuries in Siberia and across Eastern Europe, often alongside Rhodiola, another adaptogen that hails from the same region. In some people, rhubarb can cause diarrhea. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Stop using this product and call your doctor at once if you have signs of liver problems, such as: nausea, loss of appetite, upper stomach pain; itching, tired feeling; dark urine, clay-colored stools; or. J Tradit.Chin Med 1997;17(3):168-173. [Clinical observation on patients with constipation using Rhubarb and Mangxiao]. Journal of Chinese Materia Medica 1989;14(8):501-3, 512. View abstract. Jin, H. M. and Jiao, D. H. [Effect of jiang-zhi jian-fei yao on gastro-intestinal movement and adipose cell of abdominal wall]. Pharmacological activity of a herbs extract: a controlled clinical study. From diagnosis to treatment, our experts provide the care and support you need, when you need it. However, the molecular basis of its clinical effectiveness remains obscure. Lee, H. Z. Title 21. Estrovera can be purchased through the amazon.com. Learn more about the brand and its products here. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. The edible stalks are up to 45 cm long and 2.5 to 5 cm in diameter, and are used in pies, jams, jellies, sauces, and juices.1, 2, Medicinal rhubarb consists of the dried rhizome and root of R. officinale Baillon or R. palmatum, of related species/hybrids grown in China (Chinese rhubarb), or of Rheum emodi or Rheum webbianum native to India, Pakistan, or Nepal (Indian rhubarb).3, Rhubarb was first recorded and rated as one of the inferior remedies in the oldest Chinese herbal books, from 22 to 250 AD.4 In the 1780s, the active constituents responsible for the root's cathartic action and astringency were still unknown. It claims that this produces no adverse side effects. . They found that Amberen relieved many menopausal symptoms compared to the placebo group. Rhaponticum. The current state of art in . No evidence of any difference in effectiveness was found in 1 randomized clinical trial (N = 45) for the treatment of primary dysmenorrhea with rhubarb (1,260 mg twice daily beginning 2 days before menstruation and continued for the first 3 days of menstruation 3 cycles [2,520 mg/day]) compared to mefanamic acid (250 mg 3 times daily [750 mg/day]). Exploration of Emodin to treat alpha-naphthylisothiocyanate-induced cholestatic hepatitis via anti-inflammatory pathway. For example, on day 28 women taking the rhubarb extract reported an average of 5.5 fewer hot flashes than women in the placebo group, who experienced no decrease. Diarrhea may be accompanied by abdominal cramping, bloating or appetite loss. Its manufacturers claim that it can help people experiencing menopause. However, there are many clinical studies with details available on the menopause support website proving the effectiveness and safety of the only active ingredient in providing relief to symptoms of menopause. Chinese Med. Chung, K. T., Wong, T. Y., Wei, C. I., Huang, Y. W., and Lin, Y. Tannins and human health: a review. Zhonghua Nei Ke.Za Zhi. [A preliminary study on the effect of a single Rheum officinale in heavy doses in the treatment of acute icteric hepatitis]. It includes rhaponticin and desoxyrhaponticin, which are able to stimulate estrogen receptors. A dry extract from the roots of rhapontic rhubarb (extract Rheum rhaponticum (L.); ERr) has been commercially available in Germany for over two decades to treat menopausal symptoms. View abstract. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. Sept. 15, 2006 -- A pill made from rhubarb may help treat the symptoms of perimenopause, including hot flashes, according to a new . Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. This information relates to an herbal, vitamin, mineral or other dietary supplement. However, Amberen state that their products are clinically tested and comply with FDA laws and standards. View abstract. In Traditional Chinese Medicine (TCM), the rhizome and root are use to treat gastrointestinal and liver diseases. In a small study of lung cancer patients, a rhubarb extract reduced radiation-induced lung toxicity and increased pulmonary function(7). Safety and efficacy of NT, an herbal supplement, in treating human obesity. Ingredients: Black Cohosh Extract (Root and Rhizome) Lactose, Cellulose, Potato Starch, . Antiviral Res 5-15-2006; View abstract. between $10.99$21.99 . View abstract. View abstract. What is Rhapontic Rhubarb root extract good for? Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors. View abstract. Also, the product comes with a money-back guarantee which allows anyone to test if the product is effective for them or not. Zhongguo Zhong.Yao Za Zhi. It appears to have some benefits for the . The doses for rhubarb widely vary. 2000;20(2):107-109. The first reported sighting of the plant in situ was in the mountains of Bulgaria. Your email address will not be published. Long-term use can result in muscular weakness, bone loss, potassium loss, and irregular heart rhythm. Other ingredients: enteric coating, ammonium hydroxide, oleic acid, croscarmellose sodium, and others of the kind. It has been around for a long time, so there is a high probability that they offer high-quality products. Additionally, rhubarb contains a healthy dose of fiber, which contributes to good digestion, absolutely necessary for healthy weight loss. [Chinese Journal of Integrated Traditional and Western Medicine] 1986;6(8):458-459, 451. J.Tradit Chin Med 1981;3:211-213. A., and Beaulieu, A. D. Efficacy and safety of diacerein in osteoarthritis of the knee: a double-blind, placebo-controlled trial. It is also contra-indicative for women who have or are suspected to have estrogen-dependent cancer. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182. Last medically reviewed on December 23, 2021. View abstract. Research and studies on both products are limited: A 2019 study split people experiencing menopause symptoms into two groups. The feedback form on this page can be used to report content that is not accurate, up-to-date or questionable in any manner. View abstract. 1992;13(4):342-345. [Studies on polysaccharide of Rheum palmatum L.]. Effects of rhubarb tannins on renal function in rats with renal failure. Rhapontic rhubarb is used for many of the same reasons as black cohosh, and it's the active ingredient in the popular menopause supplement Estroven. Scientists tested the rhapontic rhubarb extract in a placebo . Scholze, B., Lischke, J., Hubner, D., Meyer, R. A., and Schafer, R. [Fluoride poisoning caused by rhubarb fruit juice--case report]. Learn about the difference between menopause, premenopause, and perimenopause here. Required fields are marked *. A: Menopause supplements like Estrovera may interact with patients with severe heart disease and high blood pressure. These include opioids, benzodiazepines, and alcohol. Emodin enhances cisplatin-induced cytotoxicity in human bladder cancer cells through ROS elevation and MRP1 downregulation. Potential value of plants as sources of new antifertility agents I. J Pharm Sci 1975;64:535-98. View abstract. Native to Siberian alpine meadows, Rhaponticum ( Rhaponticum carthamoides) is a perennial herb that is commonly called maral root. View abstract. You can also drag and drop the file into the provided field. We do not verify or endorse any claims made in these reviews. Amberen and Estroven are supplements that claim to reduce menopause symptoms but contain different ingredients. . But in the wake of studies that suggest HRT may increase the risk of heart diseaseheart disease and breast cancer, they are currently recommended only for short-term use. 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