https://www.health.harvard.edu/blog/the-hype-on-hyaluronic-acid-2020012318653. Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. Hyaluronic acid (HA) is a polysaccharide (a type of carbohydrate) that is widely distributed in body tissues and is found at high concentrations in the synovial fluid, vitreous humor (colorless, gel-like fluid in the eye), and skin. 2022;270:239-245. doi:10.1016/j.ejogrb.2022.01.021, Altman R, Hackel J, Niazi F, Shaw P, Nicholls M. Efficacy and safety of repeated courses of hyaluronic acid injections for knee osteoarthritis: a systematic review. This is, however, a very naive thought, based on several misunderstandings: Supplements contain the proper hyaluronic acid, i.e. Some products, like this powder, make claims about hyaluronic acid . As people age, the hyaluronic acid can break down, causing the synovial fluid to become thinner and less effective as a lubricator and shock absorber. Hyaluronan plays an important lubricating, cushioning, hydrating, immune, antioxidant, wound healing and skin repair role. Its molecule forms a three-dimensional network that acts like a sponge that literally traps water around and inside its folds. Scientists have found hyaluronic acid throughout the body, especially in eyes, joints and skin. Some experts lately have emphasized the need to restore pH balance in the blood in order to maintain a body weight that allows you to lead a healthy life. But I guess that is just from retaining more water. doi:10.1186/s13643-016-0363-9, Gocmen G, Aktop S, Tzner B, Goker B, Yarat A. Hyaluronic acid is naturally produced by the body and is used in cosmetic treatments and medical procedures for its ability to hydrate and plump the skin, as well as lubricate joints. As we age, our bodies begin to produce less and less HA, which can cause drier skin, slower tissue recovery, and less joint mobility. HA has the incredible capacity to attract and hold onto 1000x its weight in moisture. Interactions between HA and these prescription drugs are unclear. one with multiple, high-purity anti-cellulite actives in high concentrations (caffeine, forskolin, centella asiatica triterpenes are indispensable as anti-cellulite active ingredients - plus more, if possible), for 6-12 weeks. Hyaluronic acid causes only temporary edema (fluid retention) and, hence, temporary weight gain. Wounds. Yes, depending on how its used. I use the word temporary" because the body can rebuild loads of fresh 10 MDa or 20 MDa HA in just a few days, as we mentioned above. So we dont want to have too high molecular weight in our tissues, as it is a sign of a pathological process. This is similar to taking hydrolysed collagen orally, which does help with skin anti-ageing, firmness and tendon/ligament health. All in all, no, you will not get fatter if you take a hyaluronic acid supplement, neither you will get more cellulite. Best hyaluronic acid molecular weight for skincare Other benefits of HA include alleviating acid reflux symptoms and promoting wound healing. The difference between the two acid forms is how the body . (However, even inflammation has its place and it is sometimes necessary.). Dermato-endocrinology. 2021;264:118015. doi:10.1016/j.carbpol.2021.118015, Soliman F, Ye L, Jiang W, Hargest R. Targeting hyaluronic acid and peritoneal dissemination in colorectal cancer. Published January 2017. Today all HA is made by bacterial fermentation to produce the standard size of 2 MDa HA. (https://pubmed.ncbi.nlm.nih.gov/33278954/). I have been formulating hyaluronic acid serums, gels and creams for cosmetic applications since 2003 - at different concentrations and of different molecular weights, all the way from 800 Da to 2 Mda. It also plays a crucial role in wound healing by controlling. Of course its a free world and no-one is committing a crime here. Hypochlorhydria, or low stomach acid, is a commonly overlooked problem that is linked to other diseases like stomach cancer, asthma and rheumatoid arthritis. Hyaluronic acid is the skins most important hydration factor. ", Note: this is some food for thought for those ignorant experts in the media who claim that active ingredients do not penetrate the epidermis to reach the dermis for therapeutic purposes. Nutrients. No, hyaluronic acid does not directly cause weight gain but may actually aid weight loss if combined with an apt diet. 2021;13(7):2220. doi:10.3390/nu13072220, Marinho A, Nunes C, Reis S. Hyaluronic acid: a key ingredient in the therapy of inflammation. Safety: Our treatments have proven 99%+ safe over the last 12+ years (with minor/temporary irritation occurring in the other 1%- of treatments). Things are complicated with extremely low molecular weight HA. Despite the conflicting results, seek medical attention if you experience the following: Avoid hyaluronic acid derived from animal sources if you have an allergy to avian-derived products. Hyaluronic acid is a naturally occurring substance in the body and is used in cosmetic treatments and medical procedures for its hydrating and lubricating properties. Charging 230 for 30ml of hyaluronic acid (plus couple of other token ingredients, usually very cheap ones) is obscene. What Are the Best Eye Drops for Dry Eyes? This is because about 90% of it is metabolized and eliminated via expiration and urine. Scientists have found hyaluronic acid throughout the body, especially in eyes, joints and skin. Singh A, Li P, Beachley V, McDonnell P, Elisseeff JH. Verywell Health's content is for informational and educational purposes only. This seems to be the sweet spot according to studies. Pediatric Pulmonology. Taking HA is unlikely to build up in the body at excessive levels. You may want to talk to your healthcare provider about hyaluronic acid if youre interested in using it as a supplement. Although an increase in weight can be a result of rehydration, (which in turn may alleviate some of the effects of skin ageing), many women consider weight gain to be cosme 2016;45(4):S28-S33. 1 part HA and 999 parts water and perhaps some other active or inactive ingredients. This structure gives hyaluronic acid a large surface area, allowing it to bind and retain water molecules effectively. Current Medical Research and Opinion. This can be caused by a variety of factors, including heart or kidney disease, liver disease, certain medications, and hormonal imbalances. Promotes healthier, more supple skin. (8). Efficacy: As with any medical / aesthetic treatment or skin product,results vary from person to person depending on lifestyle, genetics, state of health (how each individual body responds to treatment), so specific results cannot be guaranteed. The chain has plenty of spots on it where other chemical compounds (like water, for example) can latch on. Read More Fear of weight gain is one of the main factors contributing to the poor compliance seen with hormone replacement therapy (HRT). Hyaluronic acids chain-like structure also means it can act like a scaffold structure, allowing tissues to grow. (2). 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event. Our expert physicians and surgeons provide a full range of dermatologic, reconstructive and aesthetic treatments options at Cleveland Clinic. A randomized controlled study of 100 people with osteoarthritis of the first carpometacarpal (thumb) joint showed that the intra-articular (within the joint) HA injections were superior to betamethasone (a corticosteroid) injections in improving joint function and pain. Regulation and roles of the hyaluronan system in mammalian reproduction. While it is rare to experience an allergic reaction since HA is naturally produced in your body, stop taking HA immediately and seek medical attention if you experience any signs of an allergic reaction. In small amounts they are necessary for normal function but in high amounts they can cause damage. The 20 MDa HA found in cellulite / water retention is actually produced by the body itself, without any external help, due to uncontrolled inflammation in those tissues. In a randomized, double-blind, multicenter study of 168 people with chronic leg ulcers of venous or mixed (venous and arterial) origin, the treatment with 0.2% HA cream daily for 20 weeks resulted in a higher healing rate than a neutral comparator cream. They can cause birth defects. No supplement is intended to treat, cure, or prevent disease. It is thus important to lose weight. This disaccharide has a molecular weight of 401.1 Dalton (Da). Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid features and clinical indices in knee osteoarthritis. Prescription hyaluronic acid products should be taken exactly as instructed by your healthcare provider. Does hyaluronic acid have an anti-aging effect? A typical hyaluronic acid polymer that is found in the human joint synovial fluid, i.e. Padavinangadi A, Xuan LZ, Chandrasekaran N, Johari N, Kumar N, Jetti R. The impact of eating and exercise frequency on weight gain a cross-sectional study on medical undergraduate students. More than that is simply too much, making the cream or gel too thick and uncomfortable. Hyaluronic acid is a naturally occurring substance that helps retain moisture in the skin and eyes and lubricates the joints. Oral hyaluronan relieves knee pain: a review. Hyaluronic acid does not lead to weight gain directly, as it has no caloric value. Yes. When you add moisture to the skin, you're giving the HA added water to absorb and hold onto, rather than pulling moisture out . It's also used in moisturizing creams, lotions, ointments and serums. Injectable hyaluronic acid is only used in people who don't get enough relief from other treatment options for OA of the knee. (https://pubmed.ncbi.nlm.nih.gov/32517278/). Body tissues typically use hyaluronic acid taken by mouth. That, along with antioxidant-rich plum and vegan collagen proteins . https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376784/. As we age we produce less and less HA and we are in need of protecting and boosting the levels of HA in our skin. When the long molecule breaks down into small fragments, its referred to as low molecular weight HA (LMWHA). 2020;72(3):125-130. doi:10.4081/reumatismo.2020.1272, Litwiniuk M, Krejner A, Speyrer MS, Gauto AR, Grzela T. Hyaluronic acid in inflammation and tissue regeneration. 2015;15(1). Safety of a single intra-articular injection of LBSA0103 hyaluronic acid in patients with osteoarthritis of the knee: a multicenter, single-arm, prospective, cohort study. Absorption, distribution, metabolism and excretion of hyaluronic acid during pregnancy: a matter of molecular weight. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Gupta RC, Lall R, Srivastava A, Sinha A. Hyaluronic acid: Molecular mechanisms and therapeutic trajectory. Intra-Articular Injections to Treat Joint Disorders, What To Do When You Have No Cartilage in Your Knee, non-steroidal anti-inflammatory drugs (NSAIDs). By Trang Tran, PharmD However, even if supplements are third-party tested, that doesnt mean they are safe for all or effective in general. It's a naturally occurring compound found in high amounts within the skin, joints, and eyes. The sizes above 1,000,000 Dalton form a film on the skin, while the smaller ones penetrate in the deeper skin layers. For maximum maximum results, you can use a quality serum, gel or cream containing HA. Hyaluronic Acid Type of ingredient: Hydrator Main benefits: Moisturizes skin, reduces appearance of wrinkles, replenishes cell moisture, speeds wound healing. Hyaluronic acid supplements work to improve the appearance of skin wrinkles, other signs of aging, and joint problems like osteoarthritis. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and check in about potential interactions with other supplements or medications. Published April 2015. It makes your skin flexible. Jpn J Ophthalmol. The average molecular weight of hyaluronic acid is 4 MDa in joints and about 2 MDa in skin. Its especially useful for reducing the appearance of wrinkles and age lines. A few of the different ways (available over-the-counter) that you can take hyaluronic acid include: Hyaluronic acid is also available by prescription in the following forms: Remember, only trained and qualified medical professionals should give injections. 1. deep-acting, high-power radiofrequency with high-power, deep-acting ultrasound cavitation, the most effective SAFE anti-cellulite / skin tightening technologies available today. doi:10.1016/j.semarthrit.2015.11.008, Jun JH, Bang SP, Park HS, et al. Hyaluronic acid (HA) is a natural polymer, i.e. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603175/. They can help you better understand any potential concerns. Also some foods naturally contain HA or HA precursors. Below are the top 5 reasons why you should consider trying HA to treat vaginal dryness. Policy. Research has indicated that higher molecular weight HA polymers can offer more benefits to the body. I remember the first HA we bought to use in our products in 2002 was of porcine origin. The terms Meso-CRF and LipoTherapeia are interchangeably used by us to refer to our skin tightening/non-surgical bum lifting/cellulite treatments based on ultrasound and radiofrequency. "Hyaluronic acid contains no calories, so it cannot directly lead to weight gain either. Rarely, it may cause allergic reactions. Frontiers in Veterinary Science. Efficacy of hyaluronic acid gel and spray in healing of extraction wound: a randomized controlled study. 2015;22(1):55-62. doi:10.1111/srt.12228, Abdallah MM, Fernndez N, Matias AA, Bronze M do R. Hyaluronic acid and chondroitin sulfate from marine and terrestrial sources: extraction and purification methods. 2021;11(10):1518. doi:10.3390/biom11101518, Maheu E, Rannou F, Reginster JY. Hyaluronic acid comes in various sizes (molecular weights), with the higher sizes forming a film on the skin and the smaller ones penetrating in the deeper dermal layers. Hyaluronic Acid is a polymer and it can come in varying molecular weights. Your body has about 15 grams of hyaluronic acid, and about 1/3 (one-third) of it is degraded ever day. Published April 22, 2016. A randomized multicenter clinical evaluation of sequential application of 0.3% and 0.15% hyaluronic acid for treatment of dry eye. (3). King M. Management of edema. In a randomized, prospective study comparing the efficacy and safety of intra-articular (within the joint) HA injection and betamethasone injection in people with osteoarthritis of the thumb, people who were also being treated with anti-epileptic drugs, oral anticoagulants, lithium, potassium-sparing diuretics, digoxin, minocycline, or other medications were excluded from the study. Monfort J, Rots-Sala D, Segals N, et al. Not only is HA derived from animals and bacteria, but it can also be derived from marine sources such as bivalve mollusks, the liver of stingrays, and the eyeballs of swordfish and sharks. You may wonder why the long introduction about the sizes and the gel appearance. The salt form of hyaluronic acid, namely sodium hyaluronate, is considered to be a low molecular weight HA (LMWHA). A randomized clinical trial of 76 people over 19 years of age with dry eye disease showed that applying a single drop of both 0.3% and 0.15% HA improved signs and symptoms in people with moderate to severe dry eye disease. Expert Opinion on Drug Metabolism & Toxicology. Our LipoTherapeia Celluence cellulite creams make use of the benefits of low molecular weight hyaluronic acid at optimum concentrations. On the other hand, anything above 1,000 kDa (1MDa) stays on the surface of the epidermis, with the skins native 2,000 kDa (2MDa) hyaluronan being totally unable to penetrate the epidermis. 2015;18(1):95-101. doi:10.1089/jmf.2013.0174, Abdulkareem AA, Al Marah ZA, Abdulbaqi HR, Alshaeli AJ, Milward MR. A randomized doubleblind clinical trial to evaluate the efficacy of chlorhexidine, antioxidant, and hyaluronic acid mouthwashes in the management of biofilminduced gingivitis. (https://pubmed.ncbi.nlm.nih.gov/31715233/), Visitation, mask requirements and COVID-19 information. If you are experiencing weight gain and are unsure of the cause, it is best to speak with a healthcare provider. The effect of combination therapy (glucosamine, chondroitin, and HA) on knee osteoarthritis has been studied. Vigrx Plus is made of all-natural ingredients that work together to combat the effects of erectile dysfunction. When injected into the joint, HA may cause the following: A prospective, multicenter randomized controlled trial that looked at the effectiveness of 0.2% HA cream on the skin compared to a neutral cream in the treatment of people with chronic leg ulcers reported the following treatment-related side effects. He reminds us that HA is part of the human body to begin with, so there is no reason for it to be inflammatory. Many HA serums and gels contain about 0.1% HA, i.e. Follow it up by adding jojoba oil and stir the mixture. Including burping, gas, avoiding meat, constipation, and weight gain. Well, for one, hyaluronic acid has a "high molecular weight" in its natural state, making it too large to actually sink into the skin. Scientists have also found hyaluronic acid in human embryos and are studying what role hyaluronic acid plays in reproduction and development. Carbohydrate Polymers. Here are just a few of the benefits of hyaluronic acid: Hyaluronic acid is often produced by fermenting certain types of bacteria. It is also important to note that weight gain can be caused by many factors, including diet, lifestyle, and lack of exercise. Abstract: Background: Topical delivery of molecules into the human skin is one of the main issues in dermatology and cosmetology. Not surprisingly this quite often results in permanent damage (the latest such fad is microneedling radiofrequency). But look for something that has hyaluronic acid in it which is a natural chemical our body makes which helps retains moisture by 1000x its weight. Hyaluronic acid is a highly hydrophilic (water-loving) molecule that has the ability to retain water due to its unique molecular structure. Mix well to ensure that lumps are removed. But thats another story for another article. By ensuring the skin has plenty of HA in the summer it can stay hydrated and protected from sun damage. 2019;7(3):495-499. doi:10.3889/oamjms.2019.086. Hyaluronic acid is naturally produced by the body and is used in. While pregnant do stay away from retinols which are anti aging. Hyaluronic acid: water retention, anti-aging, skin tightening, cellulite and weight gain, 16 lifestyle causes of water retention / edematous cellulite on thighs, hips and buttocks (and 41 tips to reduce it). Hyaluronic Acid Suppositories UK, hyaluronic acid vaginal gel (Hyalofemme) is used to ease vaginal dryness Italy, hyaluronic acid 5 mg suppositories with vitamin A & E were found to be a safe and effective alternative to estrogen Primary End point: Visual Analogue Scale Secondary End points: itching, burning, dyspareunia, irritation 2010;29(5):535-539. doi:10.1007/s10067-010-1372-z, Yang JJ, Zhang XM. Hyaluronic acid contains no form of calories meaning it cannot lead to weight gain. Everyone claims to be using the best type of hyaluronic acid in their products. Open Access Maced J Med Sci. Methods: Raman micro-imaging was applied to monitor the skin penetration of hyaluronic acids (HA) of different molecular weights. Research has confirmed that routinely eating fatty fish, such as salmon, tuna and trout, can reduce the risk of heart disease and death. Hyaluronic acid serums costing 230 for 30ml, which in essence should not sell more than 20 - even with all the expensive packaging taken into account. Carbohydrate Polymers. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. Peanut butter is also a good source of monounsaturated fat and antioxidants as well as vitamins and minerals that will help your body stay healthy and function properly. Hyaluronic acid and chondroitin sulfate from marine and terrestrial sources: extraction and purification methods. This can be done by avoiding excessive sun exposure; with a diet rich in vegetables, herbs and bone broth / organ meats; by drinking loads of water; and by applying a good HA skincare product, with multiple molecular weights of HA, ideally 50-300kDa. Beth Thomas, PharmD, is a clinical pharmacist and founder of BMT Consulting Services, LLC. (https://pubmed.ncbi.nlm.nih.gov/24178484/). Using a gauze containing hyaluronic acid seems to reduce the size of sores and promote healing. I have also noted a weight gain and increased appetite since taking hyaluronic acid. Creams however, are a different matter, and HA can actually increase the instability of a cream. A meta-analysis of the efficacy of hyaluronic acid eye drops for the treatment of dry eye syndrome. 2015;82(2):116-121. doi:10.1016/j.jbspin.2014.08.008, Hsu TF, Su ZR, Hsieh YH, et al. Most probably in fact, it may help, to a small extent, to reduce cellulite. Comparative efficacy of intra-articular hyaluronic acid and corticoid injections in osteoarthritis of the first carpometacarpal joint: results of a 6-month single-masked randomized study, Oral hyaluronan relieves wrinkles and improves dry skin: a 12-week double-blinded, placebo-controlled study, Hyaluronic acid: a key ingredient in the therapy of inflammation, Efficacy and safety of hyaluronic acid in the management of osteoarthritis: evidence from real-life setting trials and surveys, A randomized multicenter clinical evaluation of sequential application of 0.3% and 0.15% hyaluronic acid for treatment of dry eye, A meta-analysis of the efficacy of hyaluronic acid eye drops for the treatment of dry eye syndrome, The role of oral formulation of hyaluronic acid and chondroitin sulphate for the treatment of the patients with laryngopharyngeal reflux, Efficacy of hyaluronic acid gel and spray in healing of extraction wound: a randomized controlled study, Efficacy and safety of a hyaluronic acid-containing cream in the treatment of chronic, venous, or mixed-origin leg ulcers: a prospective, multicenter randomized controlled trial, Oral intake of a liquid high-molecular-weight hyaluronan associated with relief of chronic pain and reduced use of pain medication: results of a randomized, placebo-controlled double-blind pilot study, A randomized doubleblind clinical trial to evaluate the efficacy of chlorhexidine, antioxidant, and hyaluronic acid mouthwashes in the management of biofilminduced gingivitis, Serum hyaluronic acid levels do not explain morning stiffness in patients with fibromyalgia, Clinical efficacy of glucosamine plus sodium hyaluronate for osteoporosis complicated by knee osteoarthritis and Its influence on joint function and bone metabolic markers, Intravesical hyaluronic acid treatment in recurrent urinary tract infections in children with spina bifida and neurogenic bladder, Polycarbophil vaginal moisturizing gel versus hyaluronic acid gel in women affected by vaginal dryness in late menopausal transition: a prospective randomized trial, Efficacy and safety of repeated courses of hyaluronic acid injections for knee osteoarthritis: a systematic review, Safety of a single intra-articular injection of LBSA0103 hyaluronic acid in patients with osteoarthritis of the knee: a multicenter, single-arm, prospective, cohort study, Hyaluronic acid injection therapy for osteoarthritis of the knee: concordant efficacy and conflicting serious adverse events in two systematic reviews, Effects of hyaluronic acid on bleeding following third molar extraction, Effect of ultrasonic degradation of hyaluronic acid extracted from rooster comb on antioxidant and antiglycation activities, Versatile strategies for bioproduction of hyaluronic acid driven by synthetic biology, Targeting hyaluronic acid and peritoneal dissemination in colorectal cancer, Hyaluronic acid for the treatment of airway diseases in children: little evidence for few indications, Hyaluronic acid versus dexamethasone for the treatment of recurrent aphthous stomatitis in children: efficacy and safety analysis, Absorption, distribution, metabolism and excretion of hyaluronic acid during pregnancy: a matter of molecular weight, Nutraceutical approach to chronic osteoarthritis: from molecular research to clinical evidence, Oral hyaluronan relieves knee pain: a review, Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials, Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study, Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol, A pilot, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee, Efficacy and safety of fish oil in treatment of knee osteoarthritis, The effect of oral low molecular weight liquid hyaluronic acid combination with glucosamine and chondroitin on knee osteoarthritis patients with mild knee pain, Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid features and clinical indices in knee osteoarthritis. 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