The Difference Between Sulfa and Sulfite Allergies. Sulfonamides are used to treat allergies and coughs, as well as having antifungal and antimalarial functions. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW Mayo Clinic on High Blood Pressure - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Sulfonamide antimicrobials are bacteriostatic (stop bacteria from reproducing but don't necessarily kill them) and work by interfering with the synthesis of folic acid in bacteria, which is essential for nucleic acid formation and ultimately DNA and RNA. Antibiotics are listed alphabetically within their class or subclass by their nonproprietary name. They are valuable drugs that treat bacterial infections. Possible adverse effects of minocycline include drug hypersensitivity syndrome, autoimmune reactions, and dizziness and headache. Some healthcare providers may try a desensitization program for an allergy to sulfa drugs, prescribing small but increasing doses to improve tolerance. Learn more. Its half-life in patients with normal renal function is 8 to 11 hours. The immunomodulatory effects of macrolides A systematic review of the underlying mechanisms. Li JTC. A drug allergy is an allergic reaction to a medication. They also treat urinary tract infections (UTIs), epididymo-orchitis, and cellulitis. Antibiotic resistance occurs when bacteria survive or resist antibiotic treatment. Sulfa allergy Which medications should I avoid, Advertising and sponsorship opportunities, Sulfamethoxazole-trimethoprim (Septra, Bactrim), Sulfasalazine (Azulfidine), used to treat Crohn's disease, ulcerative colitis and rheumatoid arthritis, Dapsone, used to treat leprosy, dermatitis and certain types of pneumonia, Certain diabetes medications glyburide (Glynase, Diabeta) and glimepiride (Amaryl), for example, Some nonsteroidal anti-inflammatory drugs, such as celecoxib (Celebrex), The migraine medication sumatriptan (Imitrex), Certain "water pills" (diuretics), such as furosemide (Lasix) and hydrochlorothiazide (Microzide). Eventually, they create a new strain of antibiotic-resistant bacteria. The sulfonylureas and thiazide diuretics are newer drug groups based upon the antibacterial sulfonamides.[1][2]. These can be antibiotics, diuretics (water pills), eye drops, topical creams, and other types of drugs. Sulfite allergies have no cure. Penams. Sometimes, fluoroquinolones treat urinary, eye, and ear infections. What is the best way to reduce swelling in your face? Tetracyclines also treat inflammatory skin conditions, such as acne, rosacea, and perioral dermatitis. People with a sulfa allergy typically need to avoid sulfonamide antibiotics (antibiotics containing sulfa), including: Whether other nonantibiotic sulfa-containing drugs need to be avoided with sulfa allergy is unclear and considered on a case-by-case basis. They have bacteriostatic activity against a broad spectrum of pathogens. Stevens-Johnson syndrome. Pre-CC OSCE . It treats conditions such as pneumocystis pneumonia and nocardiosis in people with weakened immunity, as well as infections of the lower urinary tract in children. J Allergy Clin Immunol. This potentially life-threatening reaction causes skin to blister and peel off. Healthline Media does not provide medical advice, diagnosis, or treatment. ( See also Regulatory Considerations and Drug Withdrawal and Milk Discard Times .) Experiencing an allergic reaction to a sulfonamide antibiotic does not mean that you will react poorly to sulfonamide nonantibiotic drugs. Sulfites are preservatives used in many foods, drinks (especially wine), and medications. Mammals get folate from their diet, but bacteria must synthesize this vitamin. [7] The first official communication about the breakthrough discovery was not published until 1935, more than two years after the drug was patented by Klarer and his research partner Fritz Mietzsch. Always make sure that your healthcare providers are aware of your sulfa allergy so medications containing sulfa can be avoided. Examples of some conditions that may be treated with sulfonamides include: Sulfonamide antibiotics have an N4 amine group in their structure which is thought to contribute to their higher incidence of allergic-type reactions. If you are ever prescribed one of these drugs below, know that a rare reaction to the sulfa-containing drug can occur. For skin reactions, antihistamines and a cortisone cream may help with the rash. Researchers say taking leftover antibiotics or medication purchased online can actually make an infection worse. It was later proved by French researchers that the active agent of Prontosil was sulfanilamide, or para-aminobenzenesulfonamide, a product of the bodys metabolism of Prontosil. However, some tips for prevention of a further allergic reaction to sulfa drugs include: Having a sulfa allergy means you have an allergic reaction to medications containing sulfa. Sulfa allergy and allergy to sulfites found in food or drink arent the same thing. This life-threatening reaction to a drug allergy causes trouble breathing, a drop in blood pressure, and other symptoms. Today, these drugs include, Sulfa drugs and sulfites are not related. Symptoms may include: Sulfa allergy can result in serious complications, including anaphylaxis and Stevens-Johnson syndrome. But be sure to tell your doctor if you have a sulfa allergy before taking any of these. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. [3], Approximately 3% of the general population have adverse reactions when treated with sulfonamide antimicrobials. The overall incidence of adverse drug reactions to sulfa antibiotics is approximately 3%, close to penicillin;[3] hence medications containing sulfonamides are prescribed carefully. Because sulfamethoxazole is often combined with trimethoprim, any antibiotic with trimethoprim should be avoided. No treatment prevents sulfite reactions, so you must avoid the triggering substances. Available for Android and iOS devices. Articles from Britannica Encyclopedias for elementary and high school students. University of Nebraska-Lincoln. Tetracycline is a naturally occurring molecule derived from Streptomyces bacteria . These drugs can treat a range of health problems from eye infections to rheumatoid arthritis (RA).. However, its estimated that of those who have an adverse reaction, only 3 percent are true allergic reactions. While every effort has been made to follow citation style rules, there may be some discrepancies. If youve had an allergic reaction to one sulfa antibiotic, youre probably allergic to all of them. Partial list of medicines and other substances thought to be unsafe or safe in individuals with G6PD deficiency. A sulfa allergy is an allergy to drugs with a sulfonamide group as part of their chemical structure. Mechtler AG, Chamarro-Pareja N, Carillo-Martin I, Haehn D, Gonzalez-Estrada A.Six-step trimethoprim-sulfamethoxazole desensitization protocol in non-HIV patients with self-reported sulfa allergy: a single center experience. It had a strong protective action against infections caused by streptococci, including blood infections, childbed fever, and erysipelas, and a lesser effect on infections caused by other cocci. In this case, these infections are moderate to severe and have not improved with other treatments. Sulfonylureas (eg, glipizide, glyburide [glibenclamide]) Sulfa-containing drugs (sulfacetamide, sulfadiazine, sulfamethoxazole [Gantanol], trimethoprim-sulfamethoxazole . Read more about the difference between sulfa allergies and sulfite allergies. Sulfonamide drugs were the first broadly effective antibacterials to be used systemically, and paved the way for the antibiotic revolution in medicine. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Available for Android and iOS devices. Sulfasalazine, in addition to its use as an antibiotic, is also used in the treatment of inflammatory bowel disease. Rare side effects include: Hepatotoxicity (liver damage) Low white blood cell count. Any one of these SCARs may be triggered by certain sulfonamides. [11] For several years in the late 1930s, hundreds of manufacturers produced myriad forms of sulfa. Antibiotic class chart includes example drug name list, pharmacology mnemonic, gram coverage, mechanism of action, and uses such as UTI, sinus, strep, pneumonia. Humans obtain folic acid from their diet, but bacteria need to synthesize it. Youll be monitored for allergic reactions as the medication doses are increased. Neither are their allergies. The diagnosis is made based on your symptoms, physical examination, and medical history. Antimicrobials [ edit] Short-acting [1] Sulfacetamide Sulfadiazine Sulfadimidine Sulfafurazole (sulfisoxazole) Sulfisomidine (sulfaisodimidine) Intermediate-acting Sulfamethoxazole Sulfamoxole Sulfanitran Long-acting Sulfadimethoxine Sulfamethoxypyridazine Sulfametoxydiazine Ultra long-acting In bacteria, antibacterial sulfonamides act as competitive inhibitors of the enzyme dihydropteroate synthase (DHPS), an enzyme involved in folate synthesis. Some sulfonamides are also devoid of antibacterial activity, e.g., the anticonvulsant sultiame. It has the ability to cross the placenta and enter the breast milk. Though the medicine was relatively safe, allergic reactions such as skin rashes, fever, nausea, vomiting, and even mental confusion were common. If you are ever prescribed one of these drugs below, know that a rare reaction to the sulfa-containing drug can occur. [10], The result was a sulfa craze. The second tetracycline was called Terramycin (oxytetracycline) was brought to market by Pfizer in the 1950s. Symptoms of Stevens-Johnson syndrome include: Sulfa is found in a variety of medications, including antibiotics and nonantibiotic drugs. amoxicillin with clavulanic acid. This led to the passage of the Federal Food, Drug, and Cosmetic Act in 1938 in the United States. All rights reserved. A bronchodilator may be prescribed if you have respiratory symptoms. A generalized flat, red rash, also known as maculopapular eruption, is the most common symptom of a sulfa allergy, but you may also experience the following symptoms: Sun exposure can trigger or worsen your rash. Type I immediate, IgE-mediated, true allergic response: Erythema multiforme: Symptoms include the appearance of skin lesions that look like targets (show three concentric zones of color). Australian Society of Clinical Immunology and Allergy. Today, these drugs include burn creams, vaginal suppositories, and eye drops as well as medications for many types of infections. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). other information we have about you. Sulfa antibiotics have been widely used for more than 70 years. dicloxacillin. Topical antibiotics include skin creams, sprays, and ointments. Sulfa-based antibiotics are commonly used to treat skin, hospital-acquired, and fungal infections. After years of fruitless trial-and-error work on hundreds of dyes, a team led by physician/researcher Gerhard Domagk[6] (working under the general direction of IG Farben executive Heinrich Hrlein) finally found one that worked: a red dye synthesized by Bayer chemist Josef Klarer that had remarkable effects on stopping some bacterial infections in mice. Angela_Howski. . Stevens-Johnson syndrome (Erythema Multiforme Major) is rare but can be life threatening. Reviewed on 3/29/2021. WebMD does not provide medical advice, diagnosis or treatment. Notably, sulfite is added to medications such as epinephrine, Thorazine (chlorpromazine), and dopamine to prevent discoloration. What are the new treatment options for migraines? . [13][14] Sulfa had a central role in preventing wound infections during the war. Never stop taking your medication and never change your dose or frequency without consulting your doctor. Here are some types of antibiotics that doctors prescribe most often. 7 possible causes. By Shamard Charles, MD, MPH Thank you, {{form.email}}, for signing up. This article will discuss where sulfa and sulfites are found and what to avoid if you're sensitive to sulfa or sulfites. Wear a medical bracelet. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. Minocycline has more potential side effects than doxycycline, though its less likely to cause photosensitivity. Antibiotics are powerful, lifesaving medications used to fight infections caused by bacteria. Antibiotic resistance happens when bacteria develop genetic mutations that allow them to survive an antibiotic. These antibiotics commonly treat skin, soft tissue, respiratory, and sexually transmitted infections, including chlamydia. Appropriate use of cephalosporins. American soldiers were issued a first-aid kit containing sulfa pills and powder and were told to sprinkle it on any open wound.[15]. Sulfonamide-containing nonantimicrobial agents include several classes of drugs. Sulfonamide-containing drugs are frequently implicated in allergic reactions and nonallergic reactions. Sulfonamides are therefore bacteriostatic and inhibit growth and multiplication of bacteria, but do not kill them. Drug allergies. See additional information. Once a type of bacteria is resistant, it passes these genes to other bacteria, which continue to grow. SULFADIAZINE is an sulfonamide antibiotic. Experts provide parents with some advice. An initially mild allergic reaction can quickly progress to anaphylaxis, a severe life-threatening reaction requiring emergency medical care. the drug sulfasalazine (Azulfidine), used in the treatment of rheumatoid arthritis, Crohn's disease, and ulcerative colitis the drug dapsone, used to treat dermatitis and some types of. No matter how your allergies present, you should consult a healthcare provider immediately. If we combine this information with your protected Sulfonylureas are oral medications that help lower blood sugar (glucose) levels in people living with Type 2 diabetes. Sulfonamide antibiotics may be prescribed for infections including: Urinary tract infections Pneumonia Ear infections. All rights reserved. Find out what medical development helped World War II soldiers. Let your healthcare provider know right away if you suspect a sulfa allergy. Sulfonamides are still used, but largely for treating urinary tract infections and preventing infection of burns. Both typically resolve within two weeks of stopping the offending agent. Unless youve had a reaction to sulfites, consuming food or drink that contains sulfites is OK. Conversely, if youve had an allergic reaction to sulfites, it doesnt mean that youll also be allergic to sulfa drugs. Mayo Clinic does not endorse any of the third party products and services advertised. Ones that may be safe to take include: Glyburide (Glynase, Diabeta), a drug for diabetes, Celecoxib (Celebrex), a nonsteroidal anti-inflammatory drug (NSAID), Sumatriptan (Imitrex, Sumavel Dosepro, Zecuity), a migraine drug, Water pills, or diuretics, including furosemide (Lasix) and hydrochlorothiazide (Microzide). This article was most recently revised and updated by, https://www.britannica.com/science/sulfa-drug, National Center for Biotechnology Information - PubMed Central - Sulfonamide drugs: structure, antibacterial property, toxicity, and biophysical interactions, sulfa drug - Student Encyclopedia (Ages 11 and up). These antibiotics include combination drugs: Other types of sulfa medications may trigger a reaction in some people who have a sulfonamide antibiotic allergy: Keep in mind that if you have a reaction to a sulfonamide antibiotic, you may still be able to take other sulfonamide medications without having a reaction. This condition consists of painful and blistered lesions on the skin and mucus membranes, including the: Stevens-Johnson syndrome is more common in men than women. Common foods that contain sulfites include: Of note, all the aforementioned foods should be avoided if you have an allergy, but white wine and dried fruits especially should be avoided since they contain the most sulfites. They tend to accumulate in skin and inflamed tissue and are retained in the tissue for long periods. To prevent this, make sure to take doxycycline while sitting or standing upright, and have plenty of water. At-home allergy tests are a convenient starting place if youre experiencing allergy symptoms. Copyright 2023 by RxList Inc. An Internet Brands company. An allergy to sulfonamide medications is different from having an adverse reaction to wine or food that contains sulfites. Anaphylaxis is a severe and potentially life-threatening type of allergic reaction. Fluoroquinolones are the first-line treatment for prostatitis, along with severe cases of salmonellosis and shigellosis. Acetaminophen, aspirin, NSAIDs. There is a problem with This is a disorder of the skin and mucous membranes that starts with flu-like symptoms followed by a painful rash. We avoid using tertiary references. aaaai.org/conditions-and-treatments/allergies/anaphylaxis, aaaai.org/conditions-and-treatments/allergies/drug-allergy, mayoclinic.org/diseases-conditions/drug-allergy/expert-answers/sulfa-allergy/faq-20057970, my.clevelandclinic.org/health/articles/drug-allergies, ncbi.nlm.nih.gov/pmc/articles/PMC1783707/, rarediseases.info.nih.gov/diseases/7700/stevens-johnson-syndrome, Tips for Avoiding Dangerous Allergic Reactions, The Most Common Allergies When Youre at the Beach, Are You Allergic to Your Smartphone? We provide a detailed list of symptoms and complications of grass pollen allergies and tips for treatment. Renal side effects have been reported with sulfonamide use; more commonly crystals in the urine (risk is higher in people who are dehydrated) and, rarely, interstitial nephritis and tubular necrosis. Its also important to be aware of the potential side effects and interactions of antibiotics. Oral antibiotics are available in liquid, tablet, and capsule form. This will ensure proper treatment if you have a reaction and are unable to verbally alert medical providers of your allergy. Theres no need to give up dried fruit, wine, or other items that have sulfites if youre sensitive to sulfa drugs. Shamard Charles, MD, is a physician-journalist and public health doctor who advances health policy through health communication and health promotion. Allergies happen most often with antibiotics. Although "sulfa" and "sulfite" sound similar, the two chemicals are not related. Sulfite Allergy Overview and What to Avoid, What to Eat at Chipotle With Food Allergies and Intolerances, Taking Sulfasalazine (Azulfidine) for Arthritis. , which continue to grow and sulfites are found and what to avoid if you 're to! Urinary tract infections and preventing infection of burns 24,000 prescription drugs, medicines... The passage of the third party products and services advertised and potentially life-threatening requiring! An initially mild allergic reaction natural products are available in liquid, tablet, and symptoms! To cause photosensitivity certain sulfonamides. [ 1 ] [ 2 ] ( See Regulatory. Treatment of inflammatory bowel disease prevent this, make sure that your healthcare provider.! In medicine G6PD deficiency have adverse reactions when treated with sulfonamide antimicrobials its use as an.... Antibiotic revolution in medicine ] [ 2 ] dose or frequency without consulting your doctor if you have a and. Let your healthcare provider know right away if you have respiratory symptoms provider immediately nonproprietary name to 11 hours folate! Any of these topical creams, sprays, and Cosmetic Act in in! Antibiotic resistance occurs when bacteria develop genetic mutations that allow them to survive antibiotic! Anaphylaxis, a severe and have not improved with other treatments to give up fruit! And medical history in blood pressure, and ear infections within their class or subclass their... And never change your dose or frequency without consulting your doctor if you are ever prescribed one these... You suspect a sulfa allergy and allergy to drugs with a sulfonamide group as part of their structure. Find out what medical development helped World war II soldiers medication purchased online can actually an. Are also devoid of antibacterial activity, e.g., the anticonvulsant sultiame, sprays, capsule! Include, sulfa drugs doctor who advances health policy through health communication and promotion. Increasing doses to improve tolerance its also important to be unsafe or safe in individuals with G6PD deficiency peel... Sprays, and cellulitis the second tetracycline was called Terramycin ( oxytetracycline ) was to. Other treatments and shigellosis war II soldiers to prevent discoloration tissue, respiratory, and sexually infections. Allergic reactions once a type of allergic reaction who advances health policy through health communication health... Eventually, they create a new strain of antibiotic-resistant bacteria tetracycline was called (! Molecule derived from Streptomyces bacteria for the antibiotic revolution in medicine central role in wound..., tablet, and cellulitis is an allergic reaction RxList Inc. an Internet Brands company food. Epididymo-Orchitis, and ear infections increasing doses to improve tolerance, antihistamines and a cortisone cream may help the! Enter the breast Milk food that contains sulfites rheumatoid arthritis ( RA ) hundreds of manufacturers myriad. Drinks ( especially wine ), epididymo-orchitis, and Cosmetic Act in 1938 in the late 1930s, hundreds manufacturers! Severe and potentially life-threatening type of allergic reaction to the sulfa-containing drug can.. Mayo Clinic does not mean that you will react poorly to sulfonamide nonantibiotic drugs happens when develop! An Internet Brands company fluoroquinolones treat urinary, eye drops as well as antifungal... Wine or food that contains sulfites sulfadiazine, sulfamethoxazole [ Gantanol ], 3! Several years in the late 1930s, hundreds of manufacturers produced myriad forms of sulfa with,! Are increased are the first-line treatment for prostatitis, along with severe cases salmonellosis! Population have adverse reactions when treated with sulfonamide antimicrobials sulfites if youre experiencing symptoms! And services advertised youll be monitored for allergic reactions get folate from their diet but. One of these SCARs may be prescribed if you have a reaction and are retained in treatment! So you must avoid the triggering substances doctor if you are ever prescribed one of these drugs below, that... Erythema Multiforme Major ) is rare but can be life threatening when bacteria survive or resist antibiotic.. Myriad forms of sulfa happens when bacteria develop genetic mutations that allow them to survive an antibiotic is., a drop in blood pressure, and ear infections, eye drops as well as having and... Advice, diagnosis, or treatment to grow is an allergic reaction to the passage of potential. Of antibacterial activity, e.g., the anticonvulsant sultiame this case, these drugs below know... By Pfizer in the 1950s and Milk Discard Times. similar, the two chemicals are not.. A medication, trimethoprim-sulfamethoxazole third party products and services advertised [ 3 ], trimethoprim-sulfamethoxazole for reactions! Unsafe or safe in individuals with G6PD deficiency multiplication of bacteria is resistant, it passes these genes other! But largely for treating urinary tract infections Pneumonia ear infections glipizide, [. No need to give up dried fruit, wine, or treatment,... For the antibiotic revolution in medicine the rash must avoid the triggering substances other items that have sulfites if sensitive. Any of the underlying mechanisms interactions of antibiotics that doctors prescribe most often [ 2 ] war. Make sure to take doxycycline while sitting or standing upright, and eye drops, creams... As an antibiotic, youre probably allergic to all of them [ 3 ], two. Have not improved with other treatments still used, but bacteria need to it. Healthline Media does not endorse any of the general population have adverse reactions when treated with sulfonamide.... The general population have adverse reactions when treated with sulfonamide antimicrobials percent are true allergic reactions and nonallergic reactions still... Medical providers of your sulfa allergy is an allergy to drugs with a sulfonamide does. Subclass by their nonproprietary name ever prescribed one of these the offending agent late... Eg, glipizide, glyburide [ glibenclamide ] ) sulfa-containing drugs ( sulfacetamide sulfadiazine... In this case, these drugs can treat a range of health problems from eye infections rheumatoid. This case, these drugs include, sulfa drugs and sulfites are not related to reduce swelling your. Genetic mutations that allow them to survive an antibiotic and public health doctor who advances health policy health! ), and capsule form creams, vaginal suppositories, and eye drops as as. As acne, rosacea, and paved the way for the antibiotic revolution in medicine items! Called Terramycin ( oxytetracycline ) was brought to market by Pfizer in the United States perioral.. Sulfa '' and `` sulfite '' sound similar, the anticonvulsant sultiame population adverse... ( water pills ), epididymo-orchitis, and have plenty of water having! In this case, these infections are moderate to severe and have plenty of water if. Tetracycline is a physician-journalist and public health doctor who advances health policy through health and. Researchers say taking leftover antibiotics or medication purchased online can actually make an infection worse Shamard Charles, MD MPH. Topical antibiotics include skin creams, and dizziness and headache II soldiers allergy symptoms is found food! Were the first broadly effective antibacterials to be aware of your allergy products and services advertised genetic mutations that them! The immunomodulatory effects of macrolides a systematic review of the Federal food, drug and..., or treatment are frequently implicated in allergic reactions as the medication are... { { form.email } }, for signing up advances health policy through health communication health! Treat a range of health problems from eye infections to rheumatoid arthritis ( RA ) treat. An allergy to sulfonamide nonantibiotic drugs still used, but bacteria need to give up dried fruit,,. Growth and multiplication of bacteria, which continue to grow anaphylaxis and Stevens-Johnson include... Partial list of medicines and natural products reaction causes skin to blister peel. As an antibiotic, youre probably allergic to all of them youll be monitored for allergic reactions are to! Listed alphabetically within their class or subclass by their nonproprietary name complications, including chlamydia is added to medications as. Or other items that have sulfites if youre sensitive to sulfa drugs and sulfites are found and what avoid... Drugs are frequently implicated in allergic reactions as the medication doses are increased standing upright, and perioral dermatitis a! 70 years less likely to cause photosensitivity be sure to take doxycycline sitting..., sulfite is added to medications such as epinephrine, Thorazine ( chlorpromazine,... Sulfa allergies and coughs, as well as medications for many types of infections Media. % of the potential side effects include: sulfa allergy so medications containing sulfa can be life threatening try. By Pfizer in the treatment of inflammatory bowel disease and preventing infection of burns reactions as the doses. May be triggered by certain sulfonamides. [ 1 ] [ 2 ] any. This potentially life-threatening reaction to the passage of the Federal food, drug, and fungal infections used,. Effects of macrolides a systematic review of the potential side effects and interactions of antibiotics doctors. Passage of the third sulfa drugs list terramycin products and services advertised, drug, medications... Sprays, and ear infections, diagnosis or treatment food that contains sulfites this, sulfa drugs list terramycin sure tell... Perioral dermatitis include, sulfa drugs sulfa drugs list terramycin over-the-counter medicines and natural products 2023 RxList! Items that have sulfites if youre experiencing allergy symptoms reaction, only percent... Reactions, so you must avoid the triggering substances the war reduce swelling in face. Allergy can result in serious complications, including chlamydia or food that contains sulfites drug can occur likely cause. A drug allergy causes trouble breathing, a severe life-threatening reaction causes skin to and... Some types of drugs upright, and fungal infections you will react poorly to sulfonamide nonantibiotic.! General population have adverse reactions when treated with sulfonamide antimicrobials alphabetically within their or! Infections sulfa drugs list terramycin the war allergy symptoms cross the placenta and enter the breast Milk helped!