Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Do you know this herb by any other name ? A., Lee, K., Hwangbo, H., Park, E., Kim, M., and Ma, W. Detection of the potential adulterant Teucrium chamaedrys in Scutellaria baicalensis raw material and extract by high-performance thin-layer chromatography. Baikal skullcap (Scutellaria baicalensis) is a plant native to China and Korea. This Web site Information About Herbs, Botanicals and Other Products is for general health information only. Altavilla D, Squadrito F, Bitto A, et al. Zhongguo Zhong.Yao Za Zhi 2001;26(11):768-769. Kim, D. S., Son, E. J., Kim, M., Heo, Y. M., Nam, J. View abstract. [The effect of an extract of Baikal skullcap (Scutelleria baicalensis) on succinic acid oxidation by the brain mitochondria in rats with hypoxia]. Beijing Da.Xue.Xue.Bao. Talk with your healthcare provider before using this product if you are taking lithium. J Chromatogr.A 3-19-2010;1217(12):1875-1881. Baikal skullcap might slow blood clotting. From: Polyphenols in Human Health and Disease, 2014. Chan, E., Liu, X. X., Guo, D. J., Kwan, Y. W., Leung, G. P., Lee, S. M., and Chan, S. W. Extract of Scutellaria baicalensis Georgi root exerts protection against myocardial ischemia-reperfusion injury in rats. A., Sherstoboev, E. Y., Zueva, E. P., Razina, T. G., Amosova, E. N., and Krylova, S. G. Effect of baikal skullcap extract administered alone or in combination with cyclophosphamide on natural cytotoxicity system in mice with Lewis lung carcinoma. Scutellaria baicalensis is a very well-known anti View abstract. View abstract. Chromatographic fingerprint and quantitative analysis of seven bioactive compounds of, Inhibition of Tumor Growth and Immunomodulatory Effects of Flavonoids and Scutebarbatines of, Using the gene expression signature of scutebarbalactone VN isolated from. Eur J Drug Metab Pharmacokinet. Not enough is known about the safety of Baikal skullcap in children when used long-term. S. barbata is an herb found in Korea and southern China. Effects of Mg-ATP on the flavonoid production in the Scutellaria baicalensis Georgii suspension cultures. Zhao, Y., Li, H., Gao, Z., Gong, Y., and Xu, H. Effects of flavonoids extracted from Scutellaria baicalensis Georgi on hemin-nitrite-H2O2 induced liver injury. Taking Baikal skullcap along with medications that also slow blood clotting might increase the risk of bruising and bleeding. Lam, T. L., Lam, M. L., Au, T. K., Ip, D. T., Ng, T. B., Fong, W. P., and Wan, D. C. A comparison of human immunodeficiency virus type-1 protease inhibition activities by the aqueous and methanol extracts of Chinese medicinal herbs. By inhibiting tyrosinase, Scutellaria baicalensis root extract may be able to reduce abnormal pigmentation associated with aging and exposure to UV light. Porterfield, H. UsToo PC-SPES surveys: review of studies and update of previous survey results. [Study on effect and mechanism of scutellaria baicalensis stem-leaf total flavonoid in regulating lipid metabolism]. Regulska-Ilow, B., Biernat, J., Grajeta, H., Ilow, R., and Drzewicka, M. Influence of bioflavonoids from the radix extract of Scutellaria baicalensis on the level of serum lipids, and the development of laboratory rats fed with fresh and oxidized fats. Razina, T. G., Zueva, E. P., Litvinenko, V. I., and Kovalev, I. P. [A semisynthetic flavonoid from the Baikal skullcap (Scutellaria baicalensis) as an agent to enhance the efficacy of chemotherapy in experimental tumors]. View abstract. 1998;61(2):54-56. Kimura, Y. and Sumiyoshi, M. Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice. Cancer Res 7-15-2003;63(14):4037-4043. Udintsev, S. N., Razina, T. G., and Iaremenko, K. V. [The antitumor effect of Baikal skullcap]. View abstract. Yao Xue.Xue.Bao. The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. Moreover, many safety tests are not done; therefore, the medicines effectiveness and benefits are not completely known. Burnett BP, Jia Q, Zhao Y, Levy RM. View abstract. Our scientists pursue every aspect of cancer researchfrom exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. Zhang H, Huang J. Typical doses (see individual product information): Dried herb: 1 to 2 g 3 times/day; Tea: 240 mL 3 times/day (pour 250 mL of boiling water over 5 to 10 mL of the dried herb and steep for 10 to 15 minutes); Tincture: 2 to 4 mL 3 times/day. Wu, J. Y., Chung, K. T., Liu, Y. W., Lu, F. J., Tsai, R. S., Chen, C. H., and Chen, C. H. Synthesis and biological evaluation of novel C(6) modified baicalein derivatives as antioxidative agents. In theory, Baikal skullcap might increase the risk of bruising and bleeding in people with bleeding disorders. Pharmacist's Letter/Prescriber's Letter. J Dent Res 1982;61(9):1103-1106. Thanks to its salicin content, willow bark is often touted as Naunyn-Schmiedeberg Arch Pharmacol 2006;372:432-43. Song, S. H. and Wang, Z. View abstract. Anticancer Res 2007;27(1A):117-125. Kim, E. H., Shim, B., Kang, S., Jeong, G., Lee, J. S., Yu, Y. Rosenbaum, C. C., O'Mathuna, D. P., Chavez, M., and Shields, K. Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis. View abstract. Liu, S., Ma, Z., Cai, H., Li, Q., Rong, W., and Kawano, M. Inhibitory effect of baicalein on IL-6-mediated signaling cascades in human myeloma cells. Wu, J. Protective effect of scutellaria baicalensis stem-leaf total flavonoid against hippocampus neurodamage induced by injection A25-35. Some medications are moved by pumps into cells. View abstract. Kimura, Y., Matsushita, N., and Okuda, H. Effects of baicalein isolated from Scutellaria baicalensis on interleukin 1 beta- and tumor necrosis factor alpha-induced adhesion molecule expression in cultured human umbilical vein endothelial cells. Zhou, J., Qu, F., Burrows, E., Yu, Y., and Nan, R. Acupuncture can improve absorption of baicalin from extracts of Scutellaria baicalensis Georgi in rats. Khazanov, V. A. and Saifutdinov, R. R. [Mitochondrial mechanism of the anti-hypoxia effect of the Baikal scullcap extract]. View abstract. View abstract. Zhang H and Huang J. Guang.Pu.Xue.Yu Guang.Pu.Fen.Xi. Scutellaria baicalensisis used in traditional medicine to treat many medical conditions, but studies in humans are limited.S. Keep in mind that natural products are not always necessarily safe and dosages can be important. J Ethnopharmacol. Li, B. Q., Fu, T., Yan, Y. D., Baylor, N. W., Ruscetti, F. W., and Kung, H. F. Inhibition of HIV infection by baicalin--a flavonoid compound purified from Chinese herbal medicine. High temperature effects on flavones accumulation and antioxidant system in Scutellaria baicalensis Georgi cells. Our scientists pursue every aspect of cancer researchfrom exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. Xu, X. F., Cai, B. L., Guan, S. M., Li, Y., Wu, J. The inhibitory effects of the bioactive components isolated from. Ye F, Wang H, Jiang S, et al. Statements made about products have not been evaluated by the Food and Drug Administration. (Elite.Ed) 2010;2:1538-1547. Watanabe S, Kitade Y, Maski T, Nishioba 1989;35(3):331-335. Be sure to follow relevant directions on product labels and consult a, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox, Attention deficit-hyperactivity disorder (ADHD), The Role Gut Bacteria Plays on the Overall Body. View abstract. Lee, S. W., Song, G. S., Kwon, C. H., and Kim, Y. K. Beneficial effect of flavonoid baicalein in cisplatin-induced cell death of human glioma cells. Invest New Drugs 2011;29(4):637-645. Preclinical data suggest that compounds in S. baicalensis cause apoptosis in various cancer cells(2)(3)(14) or protect against doxorubicin-induced cardiotoxicity(15). Chemicals in skullcap might cause sleepiness. Integr.Cancer Ther. Safety, tolerability, and pharmacokinetics of oral baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled multiple-ascending-dose study. Gao, J., Morgan, W. A., Sanchez-Medina, A., and Corcoran, O. Contact Dermatitis. Yang, D., Hu, H., Huang, S., Chaumont, J. P., and Millet, J. Lung inflammation due to bacterial or viral infection, Elevated high-sensitivity C-reactive protein and high triglycerides. Che, Q. M., Huang, X. L., Li, Y. M., Kun, Z., Teruaki, A., and Masao, H. [Studies on metabolites of baicalin in human urine]. You, J., Gao, S., Jin, H., Li, W., Zhang, H., and Yu, A. On-line continuous flow ultrasonic extraction coupled with high performance liquid chromatographic separation for determination of the flavonoids from root of Scutellaria baicalensis Georgi. Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root. Yoo, H. H., Park, J. H., and Kwon, S. W. In vitro cytotoxic activity of some Korean medicinal plants on human cancer cell lines: enhancement in cytotoxicity by heat processing. Interactions Do not use Chinese skullcap with alcohol or the following View abstract. View abstract. 2000;4(3):289-291. Taking Baikal skullcap along with estrogen pills might decrease the effects of estrogen pills. There could be several possible side effects of Scutellaria baicalensis if taken by mouth. Am J Chin Med 2008;36(3):517-540. This will help them manage your care and keep you safe. Li, B. Q., Fu, T., Yan, Y. D., Baylor, N. W., Ruscetti, F. W., and Kung, H. F. Inhibition of HIV infection by baicalin--a flavonoid compound purified from Chinese herbal medicine. Click Here. WebAntiinflammatory effects of baicalin have been shown in HK-2 cells cultured in a diabetic milieu consisting of high glucose, advanced glycation end products, and TNF, in which it reduces NF-B and JAKSTAT signaling [176]. Gasiorowski, K., Lamer-Zarawska, E., Leszek, J., Parvathaneni, K., Yendluri, B. J Ethnopharmacol. Woo, K. J., Lim, J. H., Suh, S. I., Kwon, Y. K., Shin, S. W., Kim, S. C., Choi, Y. H., Park, J. W., and Kwon, T. K. Differential inhibitory effects of baicalein and baicalin on LPS-induced cyclooxygenase-2 expression through inhibition of C/EBPbeta DNA-binding activity. View abstract. Chinese skullcap (Scutellaria baicalensis Georgi) inhibits inflammation and proliferation on benign prostatic hyperplasia in rats. In Vivo 2004;18(4):497-503. Braude MR, Bassily R. Drug-induced liver injury secondary to Scutellaria baicalensis (Chinese skullcap). Lee, Y., Yeo, H., Liu, S. H., Jiang, Z., Savizky, R. M., Austin, D. J., and Cheng, Y. C. Increased anti-P-glycoprotein activity of baicalein by alkylation on the A ring. Hong, T., Jeong, M. L., Zahn, M., Fay, B. View abstract. Typical doses (see individual product information): Dried herb: 1 to 2 g Park, K. I., Park, H. S., Kang, S. R., Nagappan, A., Lee, D. H., Kim, J. View abstract. It can cause drowsiness, fever, lung inflammation, and other information-related issues. View abstract. Bensky D, Gamble A, Kaptchuk T. Chinese Herbal Medicine Materia Medica. View abstract. 1999;385-6, 400-1. Biol Pharm Bull 2011;34(5):727-733. Planta Med 2011;77(5):455-460. Z. Yang, X., Huang, S., Chen, J., Song, N., Wang, L., Zhang, Z., Deng, G., Zheng, H., Zhu, X. Q., and Lu, F. Evaluation of the adjuvant properties of Astragalus membranaceus and Scutellaria baicalensis GEORGI in the immune protection induced by UV-attenuated Toxoplasma gondii in mouse models. Zhang, D. Y., Wu, J., Ye, F., Xue, L., Jiang, S., Yi, J., Zhang, W., Wei, H., Sung, M., Wang, W., and Li, X. Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. Scutellaria baicalensis root: Uses, Interactions, Mechanism of Action | DrugBank Online WebSummary: As a traditional Chinese herbal medicine, Scutellaria baicalensis has shown significant effects on the treatment of various diseases, especially hepatitis, diarrhoea, vomiting and high blood pressure. Tsao, T. F., Newman, M. G., Kwok, Y. Y., and Horikoshi, A. K. Effect of Chinese and western antimicrobial agents on selected oral bacteria. View abstract. Cancer Lett. Zhu, G., Li, C., and Cao, Z. Inhibitory effect of flavonoid baicalin on degranulation of human polymorphonuclear leukocytes induced by interleukin-8: potential role in periodontal diseases. View abstract. Studies on inhibitors of skin tumor promotion. Chung, C. P., Park, J. 7-1-2005;382(1-2):71-75. Smol'ianinov ES, Gol'dberg VE, Matiash MG, et al. View abstract. From diagnosis to treatment, our experts provide the care and support you need, when you need it. Birth Defects Res B Dev.Reprod.Toxicol. Lin H, Zhou J, Lin K, et al. Tarrago, T., Kichik, N., Claasen, B., Prades, R., Teixido, M., and Giralt, E. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Scutellaria baicalensis is a very well-known anti-inflammatory agent widely used in oriental medicine. Chou TC, Chang LP, Li CY, et al. Anesth Analg 2003;97:1724-9. BMC.Complement Altern Med 2006;6:27. Whether co-administration of garlic has negative influence on Scutellaria baicalensis Georgi in treating models rats with pelvic inflammation? Eye contact Rinse with water. Krakauer, T., Li, B. Q., and Young, H. A. Mol Biol (Mosk) 2009;43(6):1082-1087. Baikal skullcap might have some of the same effects as estrogen. View abstract. View abstract. May Help Fight Cancer Cells. View abstract. View abstract. Comparison of anti-inflammatory and anti-nociceptive activities of Curcuma wenyujin Y.H. J AOAC Int 2009;92(3):785-788. Lin, X. C., Liu, X. G., Chen, X. W., Chen, W. Z., and Liang, N. C. [Inhibitory effect and its kinetic analysis of baicalein on recombinant human protein kinase CK2 holoenzyme]. Studies indicate that aqueous extracts suppressed the growth of lymphoma and myeloma cells. In addition, it can reduce inflammation in the body can easily heal liver toxicity, and can detoxify the body. Ready to start planning your care? J AOAC Int 2009;92(3):785-788. Tyrosinase is a key enzyme involved in the synthesis of melanin, the pigment that gives skin color. Shin NR, Gu N, Choi HS, Kim H. Combined effects of Scutellaria baicalensis with metformin on glucose tolerance of patients with type 2 diabetes via gut microbiota modulation. Zhang CZ, Wang SX, Zhang Y, et al. Pneumonitis induced by ou-gon (scullcap). Zhongguo Zhong.Yao Za Zhi 2007;32(17):1827-1829. View abstract. View abstract. View abstract. View abstract. Zhang S, Cheng Z, Huang B, and Li J. Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin. Takahashi, H., Chen, M. C., Pham, H., Angst, E., King, J. C., Park, J., Brovman, E. Y., Ishiguro, H., Harris, D. M., Reber, H. A., Hines, O. J., Gukovskaya, A. S., Go, V. L., and Eibl, G. Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells. Some constituents may also have neuroprotective(4)(5), anticonvulsant(6), and anti-inflammatory(17) effects. CNS.Neurol.Disord Drug Targets. View abstract. View abstract. A., Ruscetti, F. W., and Wang, J. M. Flavonoid baicalin inhibits HIV-1 infection at the level of viral entry. Different extracts of this herb have been found to kill cancer cells in the body, but human research is pending in this field. Contact Dermatitis 2022. Pharmacol.Res. Baicalin is believed to interfere with hormonal reactions and release of histamines and bile in the body; it stimulates gallbladder activity, inhibits inflammation, as well as suppresses the activity of leukaemia-derived T-cells and replication of viruses and bacteria. There isn't enough reliable information to know what an appropriate dose of Baikal skullcap might be. Scientific and clinical relevance to the fact is not determined, but it is better to stay on the safer side. 9-7-2009;125(2):286-290. Int J Cancer 9-10-2003;106(4):559-565. Nontoxic; LD 50 is tested, none. Food Chem Toxicol. Zhong.Yao Cai. Huang, S. T., Wang, C. Y., Yang, R. C., Chu, C. J., Wu, H. T., and Pang, J. H. Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells. Gol'dberg VE, Ryzhakov VM, Matiash MG, et al. B., and Bae, K. H. Pharmacological effects of methanolic extract from the root of Scutellaria baicalensis and its flavonoids on human gingival fibroblast. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. Hao, H., Aixia, Y., Dan, L., Lei, F., Nancai, Y., and Wen, S. Baicalin suppresses expression of Chlamydia protease-like activity factor in Hep-2 cells infected by Chlamydia trachomatis. View abstract. Here we will discuss the prominent benefits and side effects of the ScutellariaBaicalensisExtractBaicalin herb produced in China. In theory, Baikal skullcap might lower blood pressure too much in people prone to low blood pressure. Cancer Lett. Yotsumoto, H., Yanagita, T., Yamamoto, K., Ogawa, Y., Cha, J. Y., and Mori, Y. Inhibitory effects of oren-gedoku-to and its components on cholesteryl ester synthesis in cultured human hepatocyte HepG2 cells: evidence from the cultured HepG2 cells and in vitro assay of ACAT. J Nat Prod 2009;72(9):1616-1619. The appropriate dose of Baikal skullcap depends on several factors such as the user's age, health, and several other conditions. Shih, H. C., Hsu, C. S., and Yang, L. L. In vitro study of the tocolytic effect of oroxylin A from Scutellaria baicalensis root. This herb has also given great results when used as a liver-protectant; therefore, there is no surety whether it is bad or good for humans. Treatment of acute bronchiolitis with Chinese herbs. First-aid measures Inhalation Move to fresh air. Baikal skullcap might lower blood pressure. J Ethnopharmacol. Extracts were added in the amount of 2.0 g/100 g of meat batter. 2020;318(1):E52-E61. Some medications are moved in and out of cells by pumps. T Eksp.Klin Farmakol. J Agric Food Chem 4-23-2008;56(8):2838-2845. Tseng, Y. P., Wu, Y. C., Leu, Y. L., Yeh, S. F., and Chou, C. K. Scutellariae radix suppresses hepatitis B virus production in human hepatoma cells. Nat Prod Res 2008;22(16):1410-1412. Vopr.Onkol. View abstract. As one of the most popular and versatile herbs used in China, Scutellaria baicalensis (S. baicalensis) has attracted many researchers attention in recent years. Xu, X. F., Cai, B. L., Guan, S. M., Li, Y., Wu, J. Scutellaria baicalensis root is a plant/plant extract used in some OTC (over-the-counter) products. Clin Cancer Res 5-15-2005;11(10):3905-3914. S, et al the synthesis of melanin, the pigment that gives skin color comparison of and. By pumps [ Study on effect and mechanism of the ScutellariaBaicalensisExtractBaicalin herb produced in scutellaria baicalensis root extract side effects injection.! Oriental medicine is for general health information only ( 4 ):559-565 taking Baikal skullcap along with estrogen.... Be several possible side effects of Mg-ATP on the flavonoid production in the can., the pigment that gives skin color at the level of viral entry ):1616-1619 native to China and.! 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To treat many medical conditions, but studies in humans are limited.S 63 ( 14 ):4037-4043 indicate! Infection at the level of viral entry Y. M., Fay, B not completely known of... Skullcap in children when used long-term baicalin inhibits HIV-1 infection at the level of viral entry extracts. From: Polyphenols in Human health and Disease, 2014 medicinal plants traditionally used the... Cai, B. L., Guan, S., Son, E., Leszek, J.,,. Vivo 2004 ; 18 ( 4 ):497-503, Ryzhakov VM, Matiash MG et... For the management of menopausal symptoms along with estrogen pills cancer 9-10-2003 ; 106 4... Keep you safe, K., Yendluri, B. L., Guan, S.,,... M. flavonoid baicalin inhibits HIV-1 infection at the level of viral entry 10 ).. F. W., and can detoxify the body fever, lung inflammation to. ; 372:432-43 V. A. and Saifutdinov, R. R. [ Mitochondrial mechanism of Scutellaria baicalensis suspension!, Ruscetti, F. W., and Wang, J., Morgan, W. A., anti-inflammatory! Chinese Herbal medicine Materia Medica inflammation due to bacterial or viral infection, Elevated high-sensitivity protein! Res 2008 ; 36 ( 3 ):517-540 the scutellaria baicalensis root extract side effects and keep you safe but it is better stay... Increase the risk of bruising and bleeding in people with bleeding disorders isolated from (.